images znf717 function of liver

Sequence trace files were manually analyzed. The clinicopathologic and prognostic significance of gross classification on solitary hepatocellular carcinoma after hepatectomy. Please review our privacy policy. Cell type. Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Depth and distribution of coverage for each sequencing library based on SCG A and population sequencing B. Exome capture sequencing reveals new insights into hepatitis B virus-induced hepatocellular carcinoma at the early stage of tumorigenesis. Muscle 4. PDF 74 kb.

  • Tissue expression of ZNF Summary The Human Protein Atlas
  • GWAS Central Gene/Region
  • ZNF Gene GeneCards ZN Protein ZN Antibody

  • Hepatocellular carcinoma (HCC), the most common type of liver . 8 conserved C2H2-type zinc-finger motifs, ZNF may function in the. Summary of ZNF (X17, ZNF) expression in human tissue. Salivary gland Esophagus Tongue Stomach Duodenum Small intestine Colon Rectum Liver. The most notable characteristic was abnormal liver function, with a high.

    Video: Znf717 function of liver Immunology of Liver Disease Immunology and Medicine Volume 21

    currently no reports of mutations in SEC22B, FLG, ZNF, MUC4.
    Our results showed that ZNF knockdown in HCC cells significantly promoted cell growth, adhesion, migration and invasion, while potently inhibiting cell apoptosis in vitroas compared to the control Supplementary information, Figure S9. Download references.

    There was no evidence that could be used to evaluate liver function. Please review our privacy policy. Future work with single-cell multi-omic platforms applied to more HCCs and novel experimental models are needed for a more complete understanding of the initiation, progression and therapeutic resistance of this fatal malignancy.

    Ladomery M and Dellaire G: Multifunctional zinc finger proteins in development and disease. Detailed information on the patients was provided in a previous study 8 which focused on HBV integration detection.

    images znf717 function of liver

    images znf717 function of liver
    P2212h vs p2214h review
    Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification. Find articles by Peng Zhu.

    B Geographical sampling approach for each tumor. Previous studies have reported that confluent multinodular tumors display the highest heterogeneity of DNA ploidy compared to other types of nodular-type HCC Based on the current understanding of tumorigenesis, cancer is a genetic disease that arises from a single clone of cells expanding in an unregulated manner due to genomic instability and somatically acquired mutations 56.

    Function: There is one article specifically referring to this gene in PubMed.

    BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM. Complete information for ZNF gene (Protein Coding), Zinc Finger Protein ​, including: function, proteins, disorders, pathways, orthologs, and expression.

    Meanwhile, we identified a potential driver gene ZNF in HCC, Tumor cells were represented in red and normal liver (N1-N5) cells in green.

    Tissue expression of ZNF Summary The Human Protein Atlas

    HBV integration plays a causal role in HCC occurrence and progression.
    Support Center Support Center. DNA extracting and genome sequencing Peripheral blood samples from the proband and his parents were obtained with informed consent. Retrieved Please review our privacy policy. Project administration: Wenbiao Chen. Papavassiliou AG: Transcription factors: structure, function, and implication in malignant growth.

    images znf717 function of liver

    images znf717 function of liver
    Genet Med ; 11 —6. Imaging failed to detect liver fibrosis.

    Anticancer Res. Science China Life Sciences Other protein-altering mutations of this gene were also detected in 9 other early-stage WGS samples. The authors have no conflicts of interest to disclose. Small intestine.

    Variations in several important genes, including SEC22B, FLG, ZNF, MUC4, TRIL, CTAGE4 .

    GWAS Central Gene/Region

    characteristic was abnormal liver function, with a high level of. Zinc finger protein is a protein that in humans is encoded by the ZNF gene. Function[edit]. This gene encodes a Kruppel-associated box (KRAB). 13 Study Datasets reported containing markers in gene or region ZNF (no 5​′ and no 3′ flanks) 1,, GWAS of Alzheimer's disease (HGVST51) 1,, GWAS of drug-induced liver injury due to flucloxacillin (HGVST).
    Nat Med ; 23 — Cancer genes that are documented in the Cancer Gene Census database or have been reported as HCC driver mutations were indicated on the outer ring.

    A younger brother presented with clinical characters that were very similar to the proband. Middle panel: tumor growth curves. B Geographical sampling approach for each tumor.

    ZNF Gene GeneCards ZN Protein ZN Antibody

    Bone marrow.

    images znf717 function of liver
    Correction of hypozincemia following liver transplantation in children is associated with reduced urinary zinc loss. Introduction Hepatocellular carcinoma HCC is the third leading cause of cancer-related deaths worldwide, and hepatitis B virus HBV infection is one of its leading causes 1.

    Muscle 4. View Article : Google Scholar. Single-cell sequencing has the potential to provide new insights into cancer biological diversity that were difficult to resolve in genomic data from bulk tumor samples 89. Gene location Mouse.