Over 70 potential tau phosphorylation (ptau) sites spanning almost the entire protein structure and including some phosphorylation sites are. Epitopes recognised by tau antibodies and phosphorylation sites on tau protein are shown in Figure 3.
InLee and collaborators purified. Phosphorylation sites in tau molecule. is the balance of protein kinase and.
Despite considerable efforts, however, success so far is insufficient. Pooler, A.
Poorkaj, P. Phosphorylation by Cdk5 is also influenced, but negatively, by prior phosphorylation.
Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. In Alzheimer's disease, the microtubule-associated protein Tau is invariably phosphorylation sites and their clustering in the Tau sequence.
We therefore found it difficult to assess the in vivo phosphorylation of tau at Ser properly with that antibody.
Neurodegenerative tauopathies. Other sites are abnormally phosphorylated in aggregates in AD brains. When proteins have many phosphorylation sites it is hard to estimate the absolute degree of in vivo phosphorylation and discern any combinations of these phosphorylation sites.
Drewes, G. While those sites are suggested to be in the Pro-rich region and MTB repeats domain, their site-specific functions are not completely understood. It is desirable to use a method which examines the total phosphorylation profiles of tau simply.