Arrows depict preserved tissue. Freshly Picked. The neuroprotective effect exerted by INDP has already been reported by numerous studies. Author information Article notes Copyright and License information Disclaimer. Peer review: The authors in this paper analyzed the role of iron toxicity in the presence of high glucose, which is very interesting. Support Center Support Center. A previous study showed that the localization and levels of Nrf2 are dependent on a balance maintained by a nuclear localization sequence and a nuclear export sequence rich in leucine. The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior.
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Inflammation and spinal cord injury: Infiltrating leukocytes as determinants of injury and repair processes. Indeed, studies indicate that reduction of serum ferritin levels is beneficial for delaying or preventing cardiovascular complications in diabetic patients[ 3839 ].
Neurotoxic effects of iron overload under high glucose concentration
External link. Non-encephalitogenicity was obtained by replacing the lysine residue at position 91 with alanine. This study showed that after iron is overloaded in PC12 cells with ferric ammonium citrate, the levels of reactive oxygen species and malondialdehyde in the ferric ammonium citrate groups increased prominently in a dose-dependent manner compared with the high glucose concentration group.
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|This strategy could also induce a better neurological and morphological outcome in combination-treated animals.
Hyperglycemia was recently shown to induce oxidative stress and generate reactive oxygen species in neurons, resulting in neuronal damage and dysfunction[ 17 ].
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Rev Endocr Metab Disord. Altogether, results of this study envision a promissory therapy for SCI; however, to provide more satisfactory evidence, it is necessary to plan more investigations.
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Glial development: The crossroads of regeneration and repair in the CNS. Since no cure is currently available for this type of chronic pain, the sensitive outcome observed in these groups of rats is a promissory benefit for individuals with SCI.
New temperature modification makes the Bielschowsky silver stain reproducible.
Therefore, complications, including macrovascular and microvascular disorders cardiomyopathy, neuropathy, retinopathy, nephropathy and vascular dysfunction arteriosclerosis and hypertensionmay be enhanced in diabetic patients with increased serum and organ iron.
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The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Therapeutic window for combination therapy of A91 peptide and glutathione allows delayed treatment after spinal cord injury. This demonstrates that iron overload is responsible for the increased levels of reactive oxygen species and malondialdehyde.