The observation of venous pain is not associated with a more than usual incidence of thrombosis or thrombophlebitis at the injection site. There are no data on pregnancy exposures in primates corresponding to periods prior to the third trimester in humans. View All. Marketing Information. However, clinical data indicates that Etomidate administration in geriatric patients, particularly those with hypertension, may result in decreases in heart rate, cardiac index, and mean arterial blood pressure. Increased still born fetuses and decreased pup survival was noted at all doses tested in a study where pregnant rats were intravenously administered 0. The hemodynamic effects of Etomidate have in most cases been qualitatively similar to those of thiopental sodium, except that the heart rate tended to increase by a moderate amount following administration of thiopental under conditions where there was little or no change in heart rate following administration of Etomidate. Published juvenile animal studies demonstrate that the administration of anesthetic and sedation drugs, such as Etomidate, that either block NMDA receptors or potentiate the activity of GABA during the period of rapid brain growth or synaptogenesis, results in widespread neuronal and oligodendrocyte cell loss in the developing brain and alterations in synaptic morphology and neurogenesis. No adverse cardiovascular or respiratory effects attributable to Etomidate overdose have been reported. In other projects Wikimedia Commons.
Etomidate (USAN, INN, BAN) (marketed as Amidate) is a short-acting intravenous anaesthetic AHFS/ · Monograph · Pregnancy category In those with sepsis, one dose of the medication does not appear to affect the risk of death. Medscape - Indication-specific dosing for Amidate (etomidate), General anesthetics and sedation drugs in young children and pregnant women.
The drug Etomidate is chemically identified as required under these circumstances (consult the package insert for fentanyl before using). No exact classification is available, but these movements may also be placed into.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Video: Etomidate drug monograph definition A10: Basics of Etomidate
Pregnancy Category Risk cannot be ruled out. Limited pharmacokinetic data in patients with cirrhosis and esophageal varices suggest that the volume of distribution and elimination half-life of Etomidate are approximately double that seen in healthy subjects. Immediate recovery from anesthesia as assessed by awakening time, time needed to follow simple commands and time to perform simple tests after anesthesia as well as they were performed before anesthesiabased upon data derived from short operative procedures where intravenous Etomidate was used for both induction and maintenance of anesthesia, is about as rapid as, or slightly faster than, immediate recovery after similar use of thiopental.
Carcinogenesis, Mutagenesis, Impairment of Fertility: Carcinogenesis Long-term animal studies to evaluate the carcinogenic potential of Etomidate have not been completed.
The most frequent adverse reactions associated with use of intravenous Etomidate are transient venous pain on injection and transient skeletal muscle movements, including myoclonus:.
home drugs a-z list side effects drug center etomidate (amidate) injection. No exact classification is available, but these movements may also be. these circumstances (consult the package insert for fentanyl before using).
Drug Classification Etomidate, Injection, 2 mg/1mL, Intravenous, AGILA SPECIALTIES PRIVATE LIMITED,Not A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Cortisol levels have been reported to be suppressed up to 72 hours after a single bolus of etomidate in this population at risk for adrenal insufficiency.
Clinical and Molecular Pharmacology of Etomidate
Medically reviewed by Drugs. Marik, P. These movements sometimes resemble a localized response to some stimuli, such as venous pain on injection, in the lightly anesthetized patient averting movements.
In people with traumatic brain injury, etomidate use is associated with a blunting of an ACTH stimulation test. Published studies in animals demonstrate that the use of anesthetic agents during the period of rapid brain growth or synaptogenesis results in widespread neuronal and oligodendrocyte cell loss in the developing brain and alterations in synaptic morphology and neurogenesis.
Some published studies in children suggest that similar deficits may occur after repeated or prolonged exposures to anesthetic agents early in life and may result in adverse cognitive or behavioral effects.